prof. dr hab. inż.

Ludwik Synoradzki

Kierownik Laboratorium

t: +48 22 234 55 04
f: +48 22 625 53 17
e: ludwik.synoradzki@ch.pw.edu.pl

konsultacje:
wtorek 12–14, p. 49 (Gmach Technologii Chemicznej)

Zainteresowania naukowe:

Polimery biodegradowalne do zastosowań biomedycznych
Leki o kontrolowanym czasie uwalniania
Proleki wielkocząsteczkowe
Polimerowe nanocząstki
Skafolody polimerowe do hodowli tkanki chrzęstnej, kostnej i nabłonkowej

Dydaktyka:

Projektowanie procesów technologicznych – laboratorium (V sem., T.Chem.)
Projektowanie procesów technologicznych – seminarium (VI sem., T.Chem.)
Projektowanie procesów biotechnologicznych – laboratorium (VII sem., Biotech.)
Laboratorium technologiczne (I sem., II stopień, T.Chem.)
Optymalizacja i sterowanie procesami chemicznymi (I sem., II stopień, T.Chem.)
Technologia produktów farmaceutycznych (I sem., II stopień, T.Chem.)

Wybrane publikacje:

2018

Sebai, A.; Ruśkowski, P.; Bijak, V.; Gadomska-Gajadhur, A.; Kruk, A.; Synoradzki, L. Direct Synthesis of Polylactide (PLA)-Chlorphenesin Prodrug and Optimization Thereof with the Aid of DOE. Org. Process Res. Dev. 2018, 22, 21-26.
Kruk, A.; Gadomska-Gajadhur, A.; Dulnik, J.; Rykaczewska, I.; Ruśkowski, P.; Sebai, A.; Synoradzki, L. Evaluation of functional properties and fibroblast growth on squashy cellular scaffolds. Polymers 2018, 63, 270-274.
Budnicka, M.; Gadomska-Gajadhur, A.; Ruśkowski, P.; Synoradzki, L. Biodegradable polymers for the treatment of tuberculosis Part II. Requirements and characteristics of materials. Polymers 2018, 63, 3-9.
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2017

Basiak, D.; Dobrzycki, L.; Socha, P.; Rzepiński, P.; Plichta, A.; Bujnowski, K.; Synoradzki, L.; Orłowska, N.; Ziemkowska, W. Aminophenolates of aluminium, gallium and zinc: Synthesis, characterization and polymerization activity. Appl. Organomet. Chem. 2017, 31, e3748.
Zawada, K.; Plichta, A.; Jańczewski, D.; Hajmowicz, H.; Florjańczyk, Z.; Stępień, M.; Sobiecka, A.; Synoradzki, L. Esters of tartaric acid, a new class of potential “double green” plasticizers. ACS Sustainable Chem. Eng. 2017 5, 5999–6007.
Kruk, A.; Gadomska-Gajadhur, A.; Ruśkowski, P.; Chwojnowski, A.; Synoradzki, L. Otrzymywanie polilaktydowych rusztowań komórkowych o strukturze gąbczastej – badania wstępne i optymalizacja. Polimery 2017, 62, 118-126.
Kruk, A.; Gadomska-Gajadhur, A.; Ruśkowski, P.; Chwojnowski, A.; Dulnik, J.; Synoradzki, L. Preparation of biodegradable semi-permeable membranes as 3D scaffolds for cell cultures. Desalination and Water Treatment 2017, 64, 317-323.
Sobiecka, A.; Synoradzki, L.; Hajmowicz, H.; Zawada, K. Tartaric Acid and its Derivatives. Part 17. Synthesis and Applications of Tartrates. Organic Preparations and Procedures International 2017, 49, 1-27.
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2016

Bujnowski, K.; Synoradzki, L.; Darlak, R. C.; Zevaco, T. A.; Dinjus, E. Semi-synthetic zwitterionic rifamycins: a promising class of antibiotics; survey of their chemistry and biological activities. RSC Advances 2016, 6, 114758-114772.
Czajka, P.; Hajmowicz, H.; Synoradzki, L.; Wisialski, J.; Zawada, K. Kinetic Research of O,O′-Dibenzoyltartaric Anhydride Synthesis: Tartaric Acid and Its O-Acyl Derivatives. Part 12 Org. Process Res. Dev. 2016, 20, 1702-1708.
Krasiński, A.; Wierzba, P.; Grudzień, A.; Hajmowicz, H.; Zawada, K.; Synoradzki, L. Pervaporation applied for dewatering of reaction mixture during esterification. Chemical and Process Engineering 2016, 37, 121-131.
Tumiłowicz, P.; Synoradzki, L.; Sobiecka, A.; Arct, J.; Pytkowska, K.; Safarzyński, S. Bioactivity of Baltic amber – fossil resin. Polimery, 2016, 61, 347-356.
Kruk, A.; Gadomska-Gajadhur, A.; Ruśkowski, P.; Przybysz, A.; Bijak, V.; Synoradzki, L. Optymalizacja otrzymywania sfer polilaktydowych zawierających neomycynę, z wykorzystaniem matematycznych metod planowania doświadczeń. Przemysł Chemiczny, 2016, 95, 766-769.

2015

Strzelec, M.; Jerzak, A.; Synoradzki, L. Potentiometric determination of trace acidic impurities in lactide. Journal of Analytical Chemistry, 2015, 70, 1267-1270.
Bernaś, U.; Hajmowicz, H.; Synoradzki, L. Nucleophilic ring-opening reaction of nonsymmetrically substituted tartaric acid anhydride as a tool for the synthesis of totally differentiated tartaric acid derivatives.Tetrahedron 2015, 71, 4047–4052.
Gadomska, A.; Mierzejewska, J.; Ruśkowski, P.; Synoradzki, L. Otrzymywanie sfer polilaktydowych zawierających paracetamol. Przemysł Chemiczny, 2015, 94, 1676–1678.
Bujnowski, K.; Synoradzki, L.; Zevaco, T. A.; Dinjus, E.; Augustynowicz-Kopeć, E.; Napiórkowska, A. Rifamycin antibiotics – New compounds and synthetic methods. Part 4: Study of the reaction of 3-formylrifamycin SV with secondary amines and ketones. Tetrahedron, 2015, 71, 158-169.

2014

Gadomska, A.; Warych, I.; Ruśkowski, P.; Synoradzki, L. Otrzymywanie nanosfer polilaktydowych. Przemysł Chemiczny, 2014, 93, 1011-10014.

2013

Wisialski, J.; Sirak, J.; Synoradzki, L., Ruśkowski, P. Design and construction of the model research installation for synthesis of polylactide. Chemik 2013, 67, 220-222.
Wesela-Bauman, G.; Boinski, T.; Dominiak, P.; Hajmowicz, H.; Synoradzki, L.; Wierzbicki, M.; Woliński, B.; Woźniak, K.; Zawada, K. Tartaric acid and its O-acyl derivatives. 7. Crystal structure of O-p-anisoyl-D-tartaric acid and its dimethylammonium salt trihydrate Journal of Structural Chemistry 2013, 54, 155-158.

2012

Bujnowski, K.; Synoradzki, L.; Zevaco, T.; Dinjus, E. Rifamycin antibiotics – New compounds and synthetic methods. Part 3: Study of the reaction of 3-formylrifamycin SV with primary amines and ketones. Tetrahedron 2012, 68, 5925-5934.
Madura, I. D.; Zachara, J.; Hajmowicz, H.; Synoradzki, L. Interplay of carbonyl-carbonyl, CH⋯O and CH⋯π interactions in hierarchical supramolecular assembly of tartaric anhydrides – Tartaric acid and its O-acyl derivatives: Part 11. Journal of Molecular Structure 2012, 1017, 98-105.
Madura, I.D.; Zachara, J.; Bernaś, U.; Hajmowicz, H.; Synoradzki, L. (2R,3R)-3-O-Benzoyl-N-benzyltartramide. Acta Crystallographica Section E: Structure Reports Online 2012, 68, o1891-o1892.
Synoradzki, L.; Arct, J.; Safarzyński, S.; Hajmowicz, H.; Sobiecka, A.; Dankowska, E. Characteristics and application of Baltic amber in pharmaceutical and cosmetic industries. Przemysl Chemiczny 2012, 91, 89-94.
Włostowski, M.; Ruśkowski, P.; Synoradzki, L. Tartaric acid and its O-acyl derivatives. Part 10. Synthesis and applications of tartramides, tartrimides and O-acyltartramides and imides. 2012 Organic Preparations and Procedures International 2012, 44, 401-454.

2011

Ruśkowski, P.; Synoradzki, L.; Włostowski, M. Tartaric acid and its O-acyl derivatives. Part 8. Direct synthesis of novel N-substituted mono- and diacyltartrimides: Unusual reaction course. Arkivoc 2011 9, 142-154.
Górska, A.; Hajmowicz, H.; Kliś, T.; Serwatowski, J.; Synoradzki, L. 5-Carboxymethyl-2-(4-methylthiophenyl)-1,3,2-dioxaborolan-4-one: Synthesis, characterization and application in enantioselective reduction of ketones. Applied Organometallic Chemistry 2011, 25, 294-297.
Hajmowicz, H.; Wisialski, J.; Synoradzki, L. Direct hydrolysis of O,O′-dibenzoyltartaric anhydride – An alternative method for manufacture of the same acid: Tartaric acid and its O-acyl derivatives. Part 9 (1). Organic Process Research and Development 2011, 15, 427-434.
Madura, I.D.; Zachara, J.; Bernaś, U.; Hajmowicz, H.; Kliś, T.; Serwatowski, J.; Synoradzki, L. Interplay of O-H⋯O, C-H⋯O and carbonyl-carbonyl interactions in crystal structures of o-benzoyl-l-tartaric acid and its anhydride. Journal of Molecular Structure 2010, 984, 75-82.

2010

● Bernaś, U.; Hajmowicz, H.; Madura, I.D.; Majcher, M.; Synoradzki; L., Zawada, K. Tartaric acid and its acyl derivatives. Part 5. Direct synthesis of monoacyltartaric acids and novel mono(benzoyl)tartaric anhydride: Unusual findings in tartaric acid acylation Arkivoc 2010, (11), 1-12.

2008

● Włostowski, M.; Jańczewski, D.; Czarnocka, S.; Synoradzki, L. Rapid access to tricyclic ring system containing isoindolone by novel diastereoselective intramolecular aldol-type cyclization of N-substituted phthalimides. Synlett 2008, 20, 3198-3202.● Synoradzki, L.; Hajmowiez, H.; Wisialski, J.; Mizerski, A.; Rowicki, T. Calcium pantothenate. Part 3.1 Process for the biologically active enantiomer of the same via selective crystallization and racemization. Organic Process Research and Development 2008, 12, 1238-1244.

● Bujnowski, K.; Adamczyk-Woźniak, A.; Synoradzki, L. o-aminomethylderivatives of phenols. Part 3. Mechanistic investigation of a Mannich reaction of phenols with N-methylenealkylamines. Arkivoc 2008, 13, 106-114.

● Synoradzki, L.; Bernaś, U.; Ruśkowski, P. Tartaric acid and its O-acyl derivatives. Part 2. Application of tartaric acid and of O-acyl tartaric acids and anhydrides. Resolution of racemates. Organic Preparations and Procedures International 2008, 40, 163-200.

2007

● Bujnowski, K.; Adamczyk, A.; Synoradzki, L. o-aminomethyl derivatives of phenols. Part 2. Benzoxazines and dibenzylamines: Properties, structure, synthesis and purification. Organic Preparations and Procedures International 2007, 39, 417-446.● Zachara, J.; Madura, I.D.; Bernaś, U.; Synoradzki, L. The O,O′-diacetyl (R,R)-hydrogentartrate ester of (R)-pantolactone monohydrate. Acta Crystallographica Section E: Structure Reports Online 2007, 63 (7).

● Zachara, J.; Madura, I.D.; Bernaś, U.; Synoradzki, L. The O,O′-diacetyl (R,R)-hydrogentartrate ester of (S)-pantolactone. Acta Crystallographica Section E: Structure Reports Online 2007, 63 (7).

● Bujnowski, K.; Adamczyk, A.; Synoradzki, L. o-Aminomethyl derivatives of phenols. Part 1. Benzylamines: Properties, structure, synthesis and purification. Organic Preparations and Procedures International 2007, 39, 153-184.

2006

● Bujnowski, K.; Synoradzki, L.; Zevaco, T.; Dinjus, E.; Augustynowicz-Kopeć, E.; Zwolska, Z. Study of the reaction of 3-formylrifamycin SV with gaseous ammonia and acetone. European Journal of Organic Chemistry 2006, (18), pp. 4155-4163.● Rowicki, T.; Synoradzki, L.; Włostowski, M. Calcium pantothenate. Part 1. (R,S)-pantolactone technology improvement at the tonnage scale. Industrial and Engineering Chemistry Research 2006, 45 (4), 1259-1265.

● Synoradzki, L.; Rowicki, T.; Włostowski, M. Calcium pantothenate. Part 2. Optimisation of oxynitrilase-catalysed asymmetric hydrocyanation of 3-hydroxy-2,2-dimethylaldehyde: Synthesis of (R)-pantolactone. Organic Process Research and Development 2006, 10, 103-108.

2005

● Gliński, M.; Kościk, A.; Jerzak, A.; Synoradzki, L. Catalytic ketonisation over oxide catalysts. Part XI*. Cross-ketonisation of esters of aliphatic and aromatic acids. Polish Journal of Chemistry 2005, 79 995-1001.● Zachara, J.; Madura, I.; Hajmowicz, H.; Synoradzki, L. The hydrogen-bonding network in (+)-N-tosyl-L-glutamic acid. Acta Crystallographica Section C: Crystal Structure Communications 2005, 61, o181-o184.

● Synoradzki, L.; Ruśkowski, P.; Bernaś, U. Tartaric acid and its O-acyl derivatives. Part 1. Synthesis of tartaric acid and O-acyl tartaric acids and anhydrides.Organic Preparations and Procedures International 2005, 37, 37-63.

● Sporzyński, A.; Hofman, T.; Miśkiewicz, A.; Strutyńska, A.; Synoradzki, L. Vapor-liquid equilibrium and density of the binary system 1-phenylethylamine + toluene. Journal of Chemical and Engineering Data 2005, 50, 33-35.

● Synoradzki, L.; Jańczewski, D.; Włostowski, M. Optimisation of ethyl(2-phthalimidoethoxy)acetate synthesis with the aid of DOE. Organic Process Research and Development 2005, 9, 18-22.